Publications listed represent all or part of the research that was carried out using PNCC resources.

Check out PNCC Usage Disclaimers for information regarding acknowledgements, data sharing & publications.

Gabe Lander has provided an excellent guide for cryo-EM data validation typically expected during peer review of manuscripts.


PNCC Publications


  1. Redzic, J. S., Rahkola, J., Tran, N., Holyoak, T., Lee, E., Martin-Galiano, A. J., Meyer, N., Zheng, H., Eisenmesser, E. (2022). A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Nature Communications.
  2. Yin, Y., Zhang, F., Feng, S., Butay, K. J., Borgnia, M. J., Im, W., Lee. S. (2022). Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. Science.
  3. Faylo, J. L., Eeuwen, T., Gupta, K., Murakami, K., Christianson. D. W. (2022). Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase. Biochemistry.
  4. Jeong, H., Clark, S., Goehring, A., Dehghani-Ghahnaviyeh, S., Rasouli, A., Tajkhorshid, E., Gouaux, E. (2022). Structures of the TMC-1 complex illuminate mechanosensory transduction. Nature.
  5. Puskar, R., Du Truong, C., Swain, K., Chowdhury, S., Chan, K. Y., Li, S., Cheng, K. W., Wang, T. Y., Poh, Y. P., Mazor, Y., Liu, H. (2022). Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria.  Nature Communications.
  6. Wright, N.J., Fedor, J.G., Zhang, H., Jeong, P., Suo, Y., Yoo, J., Hong, J., Im, W. and Lee, S.Y., (2022). Methotrexate recognition by the human reduced folate carrier SLC19A1. Nature.
  7. Bonilla, S. L., Kieft, J. S. (2022). The promise of cryo-EM to explore RNA structural dynamics. Journal of Molecular Biology
  8. Bonilla, S.L., Vincens, Q., Kieft, J.S. (2022) Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA. Science.
  9. Shen, J., Wilbon, A. S., Zhou, M., Pan, Y. (2022). Mechanism of Ca2+ transport by ferroportin. Preprint on bioRxiv.
  10. Wilbon, A. S., Shen, J., Ruchala, P., Zhou, M., Pan, Y. (2022). Structural basis of ferroportin inhibition by minihepcidin PR73. Preprint on bioRxiv.
  11. Zhu, S., Sridhar, A., Teng, J., Howard, R. J., Lindahl, E., Hibbs, R. E. (2022). Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities. Nature Communications.
  12. Sun, C. Zhou, K., DePaola IV, P., Shin, W. S., Hillyer, T., Sawaya, M. R., Zhou, Z. H., Jiang, L. (2022). Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation. Preprint on bioRxiv
  13. Vasyliuk, D., Felt, J., Zhong, E. D., Berger, B., Davis, J. H., Yip, C. K. (2022). Conformational landscape of the yeast SAGA complex as revealed by cryo-EM. Scientific Reports.
  14. M. Y. Fry, V. Najdrová, A. O. Maggiolo, S. M. Saladi, P. Doležal and W. M. Clemons.  (2022). Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. Nature Structural & Molecular Biology.
  15. Ren, Z., Chhetri, A., Guan, Z., Suo, Y., Yokoyama, K., Lee, S.Y. (2022). Structural basis for inhibition and regulation of a chitin synthase from Candida albicans. Nature.
  16. Joseph, S., Schnicker, N. J., Xu, Z., Yang, T., Hopkins, J., Watkins,M., Chakravarthy, S., Davulcu, O., Anderson, M. E., Venzke, D., Campbell, K. P. (2022). Structure and mechanism of LARGE1 matriglycan polymerase. Preprint on bioRxiv.
  17. Zhao, Y., Shen, J., Wang, Q., Cao, E. (2022). Structure of the human cation-chloride cotransport KCC1 in an outward-open state. PNAS.
  18. Xiang, Y., Huang, W., Liu, H., Sang, Z., Nambulli, S., Tubiana, J., Williams, K. L. Duprex, W. P., Schneidman-Duhovny, D., Wilson, I. A., Taylor, D. J., Shi, Y. (2022). Super-immunity by broadly protective nanobodies to sarbecoviruses. Cell Reports.
  19. Kwon, D. H., Zhang, F., Fedor, J. G., Suo, Y., Lee, S.Y. (2022). Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nature.
  20. Zhao, Y., Roy, K., Vidossich, P., Cancedda, L., De Vivo, M., Forbush, B., Cao, E. (2022). Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide. Nature.
  21. Xu, Y., Han, H., Cooney, I., Guo, Y., Moran, N. G., Zuniga, N. R., Price, J. C., Hill, C. P., Shen, P. S. (2022). Active conformation of the p97-p47 unfoldase complex. Nature.
  22. Courbet, A., Hansen, J., Hsia, Y., Bethel, N., Park, Y.-J., Xu, C., Moyer, A., Boyken, S. E., Ueda, G., Nattermann, U., Nagarajan, D., Silva, D.-A., Sheffler, W., Quispe, J., Nord, A., King, N., Bradley, P., Vessler, D., Kollman, J., Baker, D. (2022). Computational design of mechanically coupled axle-rotor protein assemblies. Science.
  23. Ruben, E. A., Summers, B., Rau, M. J., Fitzpatrick, J. A. J., Di Cera, E. (2022). Cryo-EM structure of the prothrombin-prothrombinase complex. Blood.
  24. Koo, C. W., Tucci, F. J., He, Y., Rosenzweig, A. C. (2022). Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer. Science.
  25. Mahfurzur Rahman, M. D., Basta, T., Teng, J., Lee, M., Worrell, B. T., Stowell, M. H. B., Hibbs, R. E. (2022). Structural mechanism of muscle nicotinic receptor desensitization and block by curare. Nature.
  26. Prasad, V. M., Blijleven, J. S., Smit, J. M., Lee, K. K. (2022). Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery. Nature Communications.
  27. Ahn, E., Tang, T., Kim, B., Lee, H. J., Cho, U. (2022). Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids. Journal of Biological Chemistry.
  28. Gan, N., Han, Y., Zeng, W., Wang, Y., Xue, J., Jiang, Y. (2022). Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin. PNAS.
  29. Wang, C., Polovitskaya, M. M., Delgado, B. D., Jentsch, T. J., Long, S. B. (2022). Gating choreography and mechanism of the human proton - activated chloride channel ASOR. Science.
  30. Morgan, C. E., Zhang, Z., Bonomo, R. A., Yu, E. W. (2022). An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii. ASM Journals.
  31. Yang, C., Fyjiwara, R., Kim, H. J., Basnet, P., Zhu, Y., Gorbea Colon, J. J., Steimle, S., Garcia, B. A., Kaplan, C. D., Murakami, K. (2022). Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Molecular Cell.
  32. Dong, Y., Pi, X., Bartels-Burgahn, F., Saltukoglu, D., Liang, Z., Yang, J., Zheng, Y., Alt, F. W., Reth, M., Wu, H. (2022). Structural principles of B-cell antigen receptor assembly. Preprint on bioRxiv.
  33. Brawley, D. N., Sauer, D. B., Lu, J., Zheng, X., Koide, A., Jedhe, G. S., Suwatthee, T., Song, J., Arora, P. S., Koide, S., Torres, V. J., Wang, D-N., Traaseth, N., J. (2022). Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus. Nature.
  34. Donovan, B.T., Chen, H., Eek, P., Meng, Z., Jipa, C., Tan, S., Bai, L. and Poirier, M.G. (2022). Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions. Preprint on bioRxiv.
  35. Weaver, T. M., Hoitsmam N. M., Spencer, J. J., Gakhar, L., Schnicker, N. J., Freudenthal, B. D. (2022). Structural basis for APE1 processing DNA damage in the nucleosome. Preprint on bioRxiv.
  36. Yang, D., Zhao, Z., Tajkhorshid, E., & Gouaux, E. (2022). Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants. Preprint on bioRxiv.
  37. Nguyen, B. A., Afrin, S., Singh, V., Ahmed, Y., Pedretti, R., Fernandez-Ramirez, M. C., Benson, M. D., Sawaya, M., Singh, P., Cao, Q., Boyer, D., Pope, A., Wydorski, P., Kumar, S., Chhapra, F., Eisenberg, D., Saelices, L. (2022). Structural polymorphism of amyloid fibrils in cardiac transthyretin amyloidosis revealed by cryo-electron microscopy. Preprint on bioRxiv.
  38. Zane, G. M., Silveria, M. A., Meyer, N., White, T. A., Chapman, M. (2022). Cryo-EM Structure of Adeno-associated virus-4 at 2.2Å resolution. Preprint on bioRxiv.
  39. Cruz, V. E., Sekulski, K., Peddada, N., Sailer, C., Balasubramanian, S., Weirich, C. S., Stengel, F., Erzberger, J. P. (2022). Sequence-directed RNA remodeling within a topologically complex RNP substrate. Preprint on bioRxiv.
  40. Mihaljević, L., Zheng, R., Osei-Owusu, J., Lü, W., & Qiu, Z. (2022). Inhibition of the proton-activated chloride channel PAC by PIP2. Preprint on bioRxiv.
  41. Sekulski, K., Cruz, V. E., Weirich, C. S., Erzberger, J. P. (2022). rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Preprint on bioRxiv.
  42. Khandelwal, N. K., Millan, C. R., Zangari, S. I., Avila, S., Williams, D., Thaker, T. M., Tomasiak, T. M. (2022) The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation. Nature.
  43. Petrovic, S., Samanta, D., Perriches, T., Bley, C. J., Thierbach, K., Brown, B., Nie, S., Mobbs, G. W., Stevens, T. A., Liu, X., Tomaleri, G. P., Schaus, L., Hoelz, A. (2022) Architecture of the linker-scaffold in the nuclear pore. Science.



  1. Thaker, T. M., Mishra, S., Zhou, W., Faraldo-Gomez, J. D., Mchaourab, H. S., Tomasiak, T. M. (2021). Cryo-EM structure of an elusive pre-transport intermediate of the multidrug ABC transporter BmrCD reveals modes of asymmetric drug binding. Preprint on bioRxiv.
  2. Jette, C. A., Barnes, C. O., Kirk, S. M., Melillo, B., Smith III, A. B., Bjorkman, P. J. (2021). Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation. Nature Communications.
  3. Yang, C., Fujiwara, R., Kim, H. J., Basnet, P., Zhu, Y., Colón, J. J. G., Steimle, S., Garcia, B. A., Kaplan, C. D., Murakami, K. (2021). Structural visualization of de novo initiation of RNA polymerase II transcription. Molecular Cell.
  4. Driggers, C. M., Shyng, S-L. (2021). Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy. Methods in Enzymology,Ion Channels: Channel Production and Optical Methods.
  5. Sibert, B. S., Kim, J. Y., Yang, J. E., Wright, E. R. (2021). Whole-cell cryo-electron tomography of cultured and primary eukaryotic cells on micropatterned TEM grids. Preprint on bioRxiv.
  6. Caffrey, B., Zhu, X., Berezuk, A.,Tuttle, K., Chittori, S., Subramaniam, S. (2021). AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. Journal of Biological Chemistry.
  7. Novikova, I. V., Zhou, M., Du, C., Parra, M., Kim, D. N., VanAernum, Z. L., Shaw, J. B., Hellmann, H., Wysocki, V. H., Evans, J. E. (2021). Tunable Heteroassembly of a Plant Pseudoenzyme–Enzyme Complex. ACS Chemical Biology.
  8. Zhu, H., Eric Gouaux, E. (2021) Architecture and assembly mechanism of native glycine receptors. Nature.
  9. Sibert, B., S., Kim, J. Y., Yang, J. E., Ke, Z., Stobart, C. C., Moore, M. M., Wright, E. R.  (2021). Respiratory syncytial virus matrix protein assembles as a lattice with local and extended order that coordinates the position of the fusion glycoprotein. Preprint on bioRxiv.
  10. Callaway, H. M., Zyla, D., Hastie, K. M., Avalos, R. D., Agarwal, A., Bourhy, H., Corti, D., Saphire, E. O. (2021). Structure of the rabies virus glycoprotein trimer bound to a pre-fusion specific neutralizing antibody.  Preprint on bioRxiv.
  11. Courbet, A., Hansen, J., Hsia, Y., Bethel, N., Park, Y. J., Xu, C., Moyer, A., Boyken, S. E., Ueda, G., Nattermann, U., Nagarajan, D., Silva, D., Sheffler, W., Quispe, J., King, N., Bradley, P., Veesler, D., Kollman, Baker D. (2021) Computational design of nanoscale rotational mechanics in de novo protein assemblies. Preprint on bioRxiv.
  12. Yang, D., Gouaux, E. (2021) Illumination of serotonin transporter mechanism and role of the allosteric site. Science Advances.
  13. Rathinaswamy, M.K., Fleming, K.D., Dalwadi, U., Pardon, E., Harris, N.J., Yip, C.K., Steyaert, J., Burke, J.E., (2021). HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases. Structure.
  14. Ahn, E., Kim, B., Park, S., Erwin, A. L., Sung, S. H., Hovden, R., Mosalaganti, S., Cho, U. (2021) Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase.  Preprint on bioRxiv.
  15. Elferich, J., Clark, S., Ge, J., Goehring, A., Matsui, A., Gouaux, E. (2021). Molecular Structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography. eLIFE.
  16. Thaker. T. M., Mishra, S., Zhou, W., Mohan, M., Tang, Q., Faraldo-Gomez, J. D., Mchaourab, H. S., Tomasiak, T. M. (2021). Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Nature.
  17. Hu, W., Zheng, H. (2021). Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer. Communications Biology.
  18. Yang, D., Gouaux, E. (2021). Illuminations of serotonin transporter mechanism and role of the allosteric site. Science Advances.
  19. Bonilla, S.L., Sherlock, M. E., MacFadden, A., & Kieft, J. S. (2021). A viral RNA hijacks host machinery using dynamic conformational changes of a t-RNA-like structure. Science.
  20. Sung, M. W., Yang, Z., Driggers, C. M., Patton, B. L., Mostofian, B., Russo, J., Zuckerman, D. M., Shyng, S-L. (2021) Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. PNAS.
  21. Neuberger, A., Nadezhdin, K. D., & Sobolevsky, A. I. (2021). Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. Nature Communications.
  22. Lewis, T.S., Sokolova, V., Jung, H., Ng, H., Tan, D. (2021). Structural basis of chromatin regulation by histone variant H2A.Z. Nucleic Acids Research.
  23. Scortecci, J.F., Molday, L.L., Curtis, S.B., Garces, F.A., Panwar, P., Petegem, F.V., Molday, R.S. (2021) Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease. Nature Communications.
  24. Caffrey, B., Zhu, X., Berezuk, A., Tuttle, K., Chittori, S., Subramaniam, S. (2021). Common mutations of AAA ATPase p97 and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation. Journal of Biological Chemistry.
  25. Plenge, P., Yang, D., Salomon, K., Laursen, L., Kalenderoglou, I. E., Newman, A. H., Gouaux, E., Coleman, J. A., Loland, C. J. (2021) The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter. Nature.
  26. Su, C.-C., Klenotic, P. A., Cui, M., Lyu, M., Morgan C. E., Yu, E. W. (2021). Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport. PLOS Biology.
  27. Hu, Q., Botuyan, M. V., Zhao, D., Cui, G., Mer, E., Mer, G. (2021) Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation. Nature.
  28. Sweet, M. E., Larsen, C., Zhang, X., Schlame, M., Pedersen, B. P., & Stokes, D. L. (2021). Structural basis for potassium transport in prokaryotes by KdpFABC. PNAS.
  29. Lopez-Redondo, M., Fan, S., Koide, A., Koide, S., Beckstein, O., & Stokes, D. L. (2021). Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP. Journal of General Physiology.
  30. Sharif, H., Hollingsworth, L. R., Griswold, A. R., Hsiao, J. C., Wang, Q., Bachovchin, D. A., Wu, H. (2021). Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment. Immunity.
  31. Nadezhdin, K. D., Neuberger, A., Trofimov, Y. A., Krylov, N. A., Sinica, V., Kupko, N., Vlachova, V., Zakharian, E., Efremov, R. A., & Sobolevsky, A. I. (2021) Structural mechanisms of heat-induced opening of a temperature-sensitive TRP channel. Nature.
  32. Kwon, D.H., Zhang, F., Suo, Y., Bouvette, J., Borgina, M. J., and Lee, S-Y. (2021) Heat-dependent opening of TRPV1 in the presence of capsaicin. Nature Structural & Molecular Biology.
  33. Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M., and Jin, R. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature Communications.
  34. Hu, W., Parkinson, C., Zheng, H. (2021) Mechanistic Insights Revealed by YbtPQ in the Occluded State. Preprint on bioRxiv.
  35. Faylo, J.L., van Eeuwen, T., Kim, H.J., Gorbea Colón, J.J., Garcia, B.A., Murakami, K., Christianson, D.W. (2021) Structural Insight on Assembly-Line Catalysis in Terpene Biosynthesis. Nature Communications.
  36. Shen, B. W., Quispe, J. D., Luyten, Y., McGough, B. E., Morgan, R. D., & Stoddard, B. L. (2021). Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM. Structure.
  37. Rathinaswamy, M. K., Dalwadi, U., Fleming, K. D., Adams, C., Stariha, J. TB., Pardon, E., Baek, M., Vadas, O., DiMaio, F., Steyaert, J., Hansen, S. D., Yip, C. K., Burke. J. E. (2021) Structure of the phosphoinositide 3-kinase p110γ-p101 complex reveals molecular mechanism of GPCR activation. Structure.
  38. Neuberger, A., Nadezhdin, K. D., & Sobolevsky, A. I. (2021). TRPV3 expression and purification for structure determination by Cryo-EM. Ion Channels: Channel Biochemistry, Reconstruction, and Function.
  39. Yu J, Rao P, Clark S, Mitra J, Ha T, Gouaux E. (2021) Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition. Nature.
  40. Wiryanman, T. & Toor, N. (2021) Cryo-EM structure of a thermostable bacterial nanocompartment. IUCrJ.
  41. Noviello, C. M., Gharpure, A., Mukhtasimova, N., Cubuco, R., Baxter, L., Borek, D., Sine, S. M., & Hibbs, R. E. (2021). Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell.
  42. Chen, S., Lee, L., Naila, T., Fishbain, S., Wang, A., Tomkinson, A. E., Lees-Miller, S. P., & He, Y. (2021) Structural basis of long-range to short-range synaptic transition in NHEJ. Nature.
  43. Osinski, A., Black, M. H., Pawłowski, K., Chen, Z., Li, Y., & Tagliabracci, V. S. (2021). Structural and mechanistic basis for protein glutamylation by the kinase fold. Preprint on bioRxiv.
  44. Abdella, R., Talyzina, A., Chen, S., Inouye, C. J., Tjian, R., & He, Y. (2021). Structural of the human Mediator-bound transcription preinitiation complex. Science.
  45. Liu, C., Reese, R., Vu, S., Rouge, L., Shields, S. D., Kakiuchi-Kiyota, S., Chen, H., Johnson, K., Shi, Y. P., Chernov-Rogan, T., Greiner, D. M. Z., Kohli, P. B., Hackos, D., Brillantes, B., Tam, C., Li, T., Wang, J., Safina, B., Magnuson, S., Volgraf, M., Payandeh, J., Zheng, J., Rohou, A., & Chen, J. (2021). A Non-covalent Ligand Reverals Biased Agonism of the TRPA1 Ion Channel. Neuron.
  46. Hollingsworth, L. R., David, L., Li, Y., Griswold, A. R., Sharif, H., Fontana, P., Fu, T., Ruan, J., Bachovchin, D. A., & Wu, H. (2021). Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes. Nature Communications.
  47. Hollingsworth, L. R., Sharif, H., Griswold, A. R., Fontana, P., Mintseris, J., Dagbay, K. B., Paulo, J. A., Gygi, S. P., Bachovchin, D. A., & Wu, H. (2021). DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature.
  48. Sauer, D. B., Song, J., Wang, B., Hilton, J. K., Karpowich, N. K, Mindell, J. A., Rice, W. J., & Wang, D-N. (2021). Structure and inhibition mechanism of the human citrate transporter NaCT. Nature.
  49. Kato, K., Ahmad, S., Zhu, Z., Young, J. M., Mu, X., Park, S., Malik, H. S., & Hur, S. (2021). Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Molecular Cell.
  50. Herrera, M., Kim, J., Eygeris, Y., Jozic, A., & Sahay, G. (2021). Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery. Biomaterials Science.
  51. Grau, D., Zhang, Y., Lee, C-H., Valencia-Sanchez, M., Zhang, J., Wang, M., Holder, M., Svetlov, V., Tan, D., Nudler, E., Reinberg, D., Walz, T., Armache, K-J. (2021). Structures of the monomeric and dimeric PRC2:EZH2 reveal flexible modules involved in chromatin compaction. Nature Communications.
  52. Travis, B. A., Ramsey, K. M.,Prezioso, S. M., Tallo, T., Wandzilak, J. M., Hsu, A., Borgnia, M., Bartesaghi, A., Dove, S. L., Brennan, R. G., & Schumacher, M. A. (2021). Structural Basis for Virulence Activation of Francisella tularensis. Molecular Cell.
  53. Andreeva, L., David, L., Rawson, S., Shen, C., Pasricha, T., Pelegrin, P., Wu, H. (2021). NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell.



  1. Noreng, S., Posert, R., Bharadwaj, A., Houser, A., Baconguis, I. 2020. Molecular principles of assembly, activation, and inhibition in epithelial sodium channel. eLife.
  2. Zhao, Y., Shen, J., Wang, Q., Zhou, M., & Cao, E. (2020). Inhibitory and Transport Mechanisms of the Human Cation-Chloride Cotransport KCC1. Preprint on bioRxiv.
  3. Yoder, N., & Gouaux, E. (2020). Conserved His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity. eLife.
  4. Yang, J. E., Larson, M. R., Sibert, B. S., Shrum, S., & Wright, E. R. (2020). CorRelator: An interactive and flexible toolkit for high-precision cryo-correlative light and electron microscopy. Preprint on bioRxiv.
  5. Yang, X., Wang, Q., & Cao, E. (2020). Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy. Nature Communications.
  6. Wang, C., Molodtsov, V., Firlar, E., Kaelber, J., Blaha, G., Su, M., & Ebright, R. H. (2020). Structural basis of transcription-translation coupling. Science.
  7. Unchwaniwala, N., Zhan, H., Pennington, J., Horswill, M., den Boon, J. A., & Ahlquist, P. (2020). Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication. PNAS.
  8. Sobti, M., Walshe, J. L., Ishmukhametov, R., & Stewart, A. G. (2020). Visualizing movements in E. coli F1Fo ATP synthase indicates how the F1 and Fo motors are coupled. Nature Communications.
  9. Wang, Z., Rahkola, J., Redzic, J. S., Chi, Y-C., Tran, N., Holyoak, T., & Zheng, H. (2020). Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease. Nature Communications.
  10. Silveria, M. A., Large, E. E., Zane, G. M., White, T. A., & Chapman, M. S. (2020). The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors. Viruses.
  11. Santosh, V., Musayev, F., Jaiswal, R., Zárate-Pérez, F., Vandewinkel, B., Dierckx, C., Endicott, M., Sharifi, K., Dryden, K., Henckaerts, E., & Escalante, C. R. (2020). The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states. Nucleic Acids Research.
  12. Rahman, M. M., Teng, J., Worrell, B. T., Noviello, C. M., Lee, M., Karlin, A., Stowell, M. H. B., & Hibbs, R. E. (2020). Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron.
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