Publications listed represent all or part of the research that was carried out using PNCC resources.

Check out PNCC Usage Disclaimers for information regarding data sharing & publications, detailed guidance on acknowledgment use and authorship is found on the acknowledgement page.

Gabe Lander has provided an excellent guide for cryo-EM data validation typically expected during peer review of manuscripts.

 

PNCC Publications

As of April 7th, 2026, PNCC Users have published 285 peer reviewed publications with an average impact factor of 21 and a median impact factor of 19.2. During this same timeframe, over 2300 PDB depositions and over 1306 EMDB depositions have resulted from use of PNCC.

      2026
      1. "Human broadly neutralizing influenza B virus antibodies recognizing hemagglutinin computationally optimized broadly reactive antigens."    Frontiers in Immunology    DOI: 10.3389/fimmu.2026.1747235 
      2. "Cryo-EM structure of TRPM1 reveals a non-canonical architecture with an inverted transmembrane domain."    Nature Communications    DOI: 10.1038/s41467-026-70722-7 
      3. "EEPD1 evolved a unique DNA clamping dimer protecting reversed replication forks."    Nucleic Acids Research    DOI: 10.1093/nar/gkag188 
      4. "A shared amyloid fold in cardiac fibrils from three neuropathy-associated ATTR variants."    Structure    DOI: 10.1016/j.str.2026.01.013 
      5. "Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease."    Nature Communications    DOI: 10.1038/s41467-026-69563-1 
      6. "A bicistronic viral genome uses a compact type IV IRES near its 3' end to express a transmembrane protein."    Cell Reports    DOI: 10.1016/j.celrep.2026.116982 
      7. "Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis."    Science Advances    DOI: 10.1126/sciadv.aeb4249 
      8. "Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM."    Nature Communications    DOI: 10.1038/s41467-026-68311-9 
      9. "Structural basis for the subtype-selectivity of KCa2.2 channel activators."    Nature Communications    DOI: 10.1038/s41467-025-67232-3 
      10. "Amyloid fibril polymorphism in the heart and liver of a patient with polyneuropathic ATTRv-V122Δ amyloidosis."    Communications Biology    DOI: 10.1038/ s42003-026-09919-x 
      11. "Oligomeric defects in soybean serine hydroxymethyltransferase 8: tetramer destabilization by A149T and other variants associated with soybean cyst nematode resistance."    The FEBS Journal    DOI: 10.1111/febs.70528 
      2025
      1. "Streptococcus pneumoniaeHtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes."    Protein Science    DOI: 10.1002/pro.70411 
      2. "Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2516318122 
      3. "Size-Dependent Optical Band Gaps in Metal-Organic Framework Nanoparticles."    Journal of the American Chemical Society    DOI: 10.1021/jacs.5c18410 
      4. "The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity"    Nature Communications    DOI: 10.1038/s41467-025-65799-5 
      5. "Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2524034122 
      6. "SINE compounds activate exportin 1 degradation through an allosteric mechanism."    Nature Chemical Biology    DOI: 10.1038/s41589-025-02058-0 
      7. "Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs."    Communications Biology    DOI: 10.1038/s42003-025-08955-3 
      8. "Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex."    Science    DOI: 10.1126/science.adr9755 
      9. "Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria."    Journal of Medicinal Chemistry    DOI: 10.1021/acs.jmedchem.5c02394 
      10. "Structure and activation of the Drosophila insulin receptor by three Drosophila insulin-like peptides."    Nature Communications    DOI: 10.1038/s41467-025-64586-6 
      11. "Human monoclonal antibodies to HPV16 show evidence for common developmental pathways and public epitopes."    PLOS Pathogens    DOI: 10.1371/journal.ppat.1013086 
      12. "Structural and molecular homogeneity of ATTRv-T60A amyloid fibrils across patients and organs."    Structure    DOI: 10.1016/j.str.2025.09.008  
      13. "LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan."    Nature Communications    DOI: 10.1038/s41467-025-64080-z 
      14. "Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production."    Angewandte Chemie International Edition    DOI: 10.1002/anie.202510234 
      15. "Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements."    Science Advances    DOI: 10.1126/sciadv.adx4647 
      16. "A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site in"    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2505710122 
      17. "Time-Resolved Fluorescence Imaging and Correlative Cryo-Electron Tomography to Study Structural Changes of the HIV-1 Capsid."    ACS Nano    DOI: 10.1021/acsnano.5c06724 
      18. "Activation of kainate receptor GluK2–Neto2 complex"    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-025-01656-9 
      19. "Cryo-EM reveals molecular mechanisms underlying the inhibitory effect of netrin-4 on laminin matrix formation."    Nature Communications    DOI: 10.1038/s41467-025-62814-7 
      20. "Using Design of Experiments to Optimize CryoEM Grids for Membrane Proteins."    Microscopy and Microanalysis    DOI: 10.1093/mam/ozaf048.508 
      21. "Conduction pathway for potassium through the Escherichia coli pump KdpFABC."    eLife    DOI: 10.7554/eLife.107397 
      22. "The bile acid-sensitive ion channel is gated by Ca2+-dependent conformational changes in the transmembrane domain."    Nature Communications    DOI: 10.1038/s41467-025-62038-9 
      23. "Structural basis of the inhibition of TRPV1 by analgesic sesquiterpenes."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2506560122 
      24. "Structural serology of polyclonal antibody responses to mRNA-1273 and NVX-CoV2373 COVID-19 vaccines."    Cell Reports    DOI: 10.1016/j.celrep.2025.115986 
      25. "Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2421362122 
      26. "Biophysical basis of tight junction barrier modulation by a pan-claudin binding molecule."    PNAS Nexus    DOI: 10.1093/pnasnexus/pgaf189 
      27. "A surface lipoprotein on Pasteurella multocida binds complement factor I to promote immune evasion."    PLOS Pathogens    DOI: 10.1371/journal.ppat.1012686 
      28. "Water-directed pinning is key to tau prion formation."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2421391122 
      29. "Structural basis of lipid transfer by a bridge-like lipid-transfer protein."    Nature    DOI: 10.1038/s41586-025-08918-y 
      30. "Mechanism of small heat shock protein client sequestration and induced polydispersity."    Nature Communications    DOI: 10.1038/s41467-025-58964-3 
      31. "Cryo-EM structures of PP2A:B55 with p107 and Eya3 define substrate recruitment."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-025-01535-3 
      32. "Structure and infection dynamics of mycobacteriophage Bxb1."    Cell    DOI: 10.1016/j.cell.2025.03.027 
      33. "Cryo-EM structures of DNA-free and DNA-bound BsaXI: architecture of a Type IIB restriction-modification enzyme."    Nucleic Acids Research    DOI: 10.1093/nar/gkaf291 
      34. "Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH."    Nature Communications    DOI: 10.1038/s41467-025-58202-w 
      35. "The RAD52 double-ring remodels replication forks restricting fork reversal."    Nature    DOI: 10.1038/s41586-025-08753-1 
      36. "Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids."    Nature Communications    DOI: 10.1038/s41467-025-58298-0 
      37. "A novel "bio-tag" for cryo-EM studies based on the small, electron-dense protein Csp1."    Biophysical Journal    DOI: 10.1016/j.bpj.2025.03.018 
      38. "Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β."    Nature Communications    DOI: 10.1038/s41467-025-57915-2 
      39. "Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5."    Nature Communications    DOI: 10.1038/s41467-025-57752-3 
      40. "Evolutionary adaptations of doublet microtubules in trypanosomatid parasites."    Science    DOI: 10.1126/science.adr5507 
      41. "Structural basis of a distinct α-synuclein strain that promotes tau inclusion in neurons."    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2025.108351 
      42. "Production and cryo-electron microscopy structure of an internally tagged SARS-CoV-2 spike ecto-domain construct."    Journal of Structural Biology: X    DOI: 10.1016/j.yjsbx.2025.100123 
      43. "The structure of full-length AFPK supports the ACP linker in a role that regulates iterative polyketide and fatty acid assembly."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2419884122 
      44. "Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting."    Nucleic Acids Research    DOI: 10.1093/nar/gkaf033  
      45. "Structural basis for human NKCC1 inhibition by loop diuretic drugs."    The EMBO Journal    DOI: 10.1038/s44318-025-00368-6  
      46. "Discovery of three novel neutralizing antibody epitopes on the human astrovirus capsid spike and mechanistic insights into virus neutralization."    Journal of Virology    DOI: 10.1128/jvi.01619-24 
      47. "Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-024-01479-0 
      48. "Human P2X4 receptor gating is modulated by a stable cytoplasmic cap and a unique allosteric pocket."    Science Advances    DOI: 10.1126/sciadv.adr3315 
      49. "RNA control of reverse transcription in a diversity-generating retroelement."    Nature    DOI: 10.1038/s41586-024-08405-w 
      50. "Structural diversity of axonemes across mammalian motile cilia."    Nature    DOI: 10.1038/s41586-024-08337-5 
      2024
      1. "Structures of methane and ammonia monooxygenases in native membranes."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2417993121 
      2. "Structural and functional dynamics of human cone cGMP-phosphodiesterase important for photopic vision."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2419732121 
      3. "Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin."    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2024.108133 
      4. "Streptococcus pneumoniae GAPN is a key metabolic player necessary for host infection."    Protein Science    DOI: 10.1002/pro.5253 
      5. "Structural insights into subunit-dependent functional regulation in epithelial sodium channels."    Structure    DOI: 10.1016/j.str.2024.11.013 
      6. "AI-Based Discovery and CryoEM Structural Elucidation of a KATP Channel Pharmacochaperone."    eLife    DOI: 10.7554/eLife.103159.1 
      7. "Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM."    Nature Communications    DOI: 10.1038/s41467-024-54647-7 
      8. "Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus."    Journal of Cell Biology    DOI: 10.1083/jcb.202408193 
      9. "rapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channels."    Nature Communications    DOI: 10.1038/s41467-024-54538-x 
      10. "Structural basis for Retriever-SNX17 assembly and endosomal sorting."    Nature Communications    DOI: 10.1038/s41467-024-54583-6 
      11. "Structures of the multi-domain oxygen sensor DosP: remote control of a c-di-GMP phosphodiesterase by a regulatory PAS domain."    Nature Communications    DOI: 10.1038/s41467-024-53942-7 
      12. "Structure-function analyses of human TRPV6 ancestral and derived haplotypes."    Structure    DOI: 10.1016/j.str.2024.10.018  
      13. "ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity."    Structure    DOI: 10.1016/j.str.2024.09.021 
      14. "Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4."    Structure    DOI: 10.1016/j.str.2024.09.015  
      15. "P2X7 receptors exhibit at least three modes of allosteric antagonism"    Science Advances    DOI: 10.1126/sciadv.ado5084 
      16. "Cryo-EM structures of the human P2X1 receptor reveal subtype-specific architecture and antagonism by supramolecular ligand-binding."    Nature Communications    DOI: 10.1038/s41467-024-52636-4 
      17. "Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway."    Science Advances    DOI: 10.1126/sciadv.adp2221 
      18. "Structures of the Mycobacterium tuberculosis efflux pump EfpA reveal the mechanisms of transport and inhibition."    Nature Communications    DOI: 10.1038/s41467-024-51948-9 
      19. "Structural analysis of noncanonical translation initiation complexes."    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2024.107743 
      20. "High-resolution reconstruction of a C. elegans ribosome sheds light on evolutionary dynamics and tissue specificity"    RNA    DOI: 10.1261/rna.080103.124 
      21. "Cryo-EM reveals a phosphorylated R-domain envelops the NBD1 catalytic domain in an ABC transporter."    Life Science Alliance    DOI: 10.26508/lsa.202402779 
      22. "Structural bases for Na+-Cl- cotransporter inhibition by thiazide diuretic drugs and activation by kinases."    Nature Communications    DOI: 10.1038/s41467-024-51381-y  
      23. "Multi-layered heterochromatin interaction as a switch for DIM2-mediated DNA methylation."    Nature Communications    DOI: 10.1038/s41467-024-51246-4 
      24. "Structural basis of RfaH-mediated transcription–translation coupling"    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-024-01372-w 
      25. "Structure of the human dopamine transporter and mechanisms of inhibition."    Nature    DOI: 10.1038/s41586-024-07739-9 
      26. "High-affinity agonism at the P2X7 receptor is mediated by three residues outside the orthosteric pocket."    Nature Communications    DOI: 10.1038/s41467-024-50771-6 
      27. "Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria."    Cell Chemical Biology    DOI: 10.1016/j.chembiol.2024.07.001 
      28. "Assembly of respiratory syncytial virus matrix protein lattice and its coordination with fusion glycoprotein trimers."    Nature Communications    DOI: 10.1038/s41467-024-50162-x 
      29. "Priming antibody responses to the fusion peptide in rhesus macaques."    npj Vaccines    DOI: 10.1038/s41541-024-00918-9 
      30. "Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2403333121 
      31. "Structural insights into GABAA receptor potentiation by Quaalude."    Nature Communications    DOI: 10.1038/s41467-024-49471-y 
      32. "Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-024-01335-1 
      33. "Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment."    Communications Biology    DOI: 10.1038/s42003-024-06437-6 
      34. "2098-LB: Identification and Structural Elucidation of a Novel KATP Channel Modulator Demonstrating Dual Pharmacochaperone and Inhibitory Actions."    Diabetes    DOI: 10.2337/db24-2098-LB 
      35. "Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain."    Journal of Thrombosis and Haemostasis    DOI: 10.1016/j.jtha.2024.05.024 
      36. "Structural and Biochemical Characterization of the Nucleosome Containing Variants H3.3 and H2A.Z."    Epigenomes    DOI: 10.3390/epigenomes8020021 
      37. "Kainate receptor channel opening and gating mechanism."    Nature    DOI: 10.1038/s41586-024-07475-0 
      38. "mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies."    Science    DOI: 10.1126/science.adk0582 
      39. "Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA."    eLife    DOI: 10.7554/eLife.93979.3 
      40. "Structural transitions enable interleukin-18 maturation and signaling."    Immunity    DOI: 10.1016/j.immuni.2024.04.015 
      41. "TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site."    Science Advances    DOI: 10.1126/sciadv.adn2453 
      42. "Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2."    Nature Communications    DOI: 10.1038/s41467-024-48028-3 
      43. "Bacterial selenocysteine synthase structure revealed by single-particle cryoEM."    Current Research in Structural Biology    DOI: 10.1016/j.crstbi.2024.100143 
      44. "NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks."    Cell    DOI: 10.1016/j.cell.2024.03.008 
      45. "Structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930."    Cell Reports    DOI: 10.1016/j.celrep.2024.114108 
      46. "Structural mechanisms for VMAT2 inhibition by tetrabenazine."    eLife    DOI: 10.7554/eLife.91973.4 
      47. "A suite of designed protein cages using machine learning and protein fragment-based protocols."    Structure    DOI: 10.1016/j.str.2024.02.017 
      48. "Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface."    Nature Communications    DOI: 10.1038/s41467-024-46751-5 
      49. "Structure and assembly of a bacterial gasdermin pore."    Nature    DOI: 10.1038/s41586-024-07216-3 
      50. "Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin."    Nature Communications    DOI: 10.1038/s41467-024-45958-w 
      51. "Mechanistic Insights Revealed by YbtPQ in the Occluded State."    Biomolecules    DOI: 10.3390/biom14030322 
      52. "Structural bases for stoichiometry‐selective calcium potentiation of a neuronal nicotinic receptor."    British Journal of Pharmacology    DOI: 10.1111/bph.16321 
      53. "Antiviral drug recognition and elevator-type transport motions of CNT3."    Nature Chemical Biology    DOI: 10.1038/s41589-024-01559-8 
      54. "Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance"    Science Advances    DOI: 10.1126/sciadv.adj3864 
      55. "Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation."    Cell    DOI: 10.1016/j.cell.2024.01.032 
      56. "Mechanisms of RNF168 nucleosome recognition and ubiquitylation."    Molecular Cell    DOI: 10.1016/j.molcel.2023.12.036 
      57. "The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function."    Structure    DOI: 10.1016/j.str.2023.12.015 
      58. "Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy."    Nature Communications    DOI: 10.1038/s41467-024-44820-3 
      59. "Overcoming resolution attenuation during tilted cryo-EM data collection."    Nature Communications    DOI: 10.1038/s41467-023-44555-7 
      60. "Mechanism of anion exchange and small-molecule inhibition of pendrin."    Nature Communications    DOI: 10.1038/s41467-023-44612-1 
      2023
      1. "Structural basis for DNA proofreading."    Nature Communications    DOI: 10.1038/s41467-023-44198-8 
      2. "B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan’s syndrome mutations"    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2310727120 
      3. "Cryo-EM structures of PP2A:B55–FAM122A and PP2A:B55–ARPP19"    Nature    DOI: 10.1038/s41586-023-06870-3 
      4. "Structural basis for flagellin-induced NAIP5 activation."    Science Advances    DOI: 10.1126/sciadv.adi8539 
      5. "Structural basis of Gabija anti-phage defence and viral immune evasion."    Nature    DOI: 10.1038/s41586-023-06855-2 
      6. "Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery."    Journal of Molecular Biology    DOI: 10.1016/j.jmb.2023.168365 
      7. "Product analogue binding identifies the copper active site of particulate methane monooxygenase."    Nature Catalysis    DOI: 10.1038/s41929-023-01051-x 
      8. "Energy coupling and stoichiometry of Zn2+/H+ antiport by the prokaryotic cation diffusion facilitator YiiP."    eLife    DOI: 10.7554/eLife.87167.3 
      9. "Molecular pharmacology of the onco-TRP channel TRPV6."    Channels    DOI: 10.1080/19336950.2023.2266669 
      10. "Structural basis of promiscuous substrate transport by Organic Cation Transporter 1."    Nature Communications    DOI: 10.1038/s41467-023-42086-9 
      11. "Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 Ã… Resolution Reveals New Details of Non-Myosin Proteins."    International Journal of Molecular Sciences    DOI: 10.3390/ijms241914936 
      12. "A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM."    Nucleic Acids Research    DOI: 10.1093/nar/gkad784 
      13. "Pentameric TRPV3: An artifact or a clue to channel function?."    Cell Calcium    DOI: 10.1016/j.ceca.2023.102812 
      14. "Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology."    Nature    DOI: 10.1038/s41586-023-06556-w 
      15. "Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2"    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-023-01080-x 
      16. "Structural insights into opposing actions of neurosteroids on GABAA receptors."    Nature Communications    DOI: 10.1038/s41467-023-40800-1 
      17. "Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin."    Nature Communications    DOI: 10.1038/s41467-023-40362-2 
      18. "Structure of an endogenous mycobacterial MCE lipid transporter."    Nature    DOI: 10.1038/s41586-023-06366-0 
      19. "Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex"    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2301199120 
      20. "Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2304602120 
      21. "Structural basis of TFIIIC-dependent RNA polymerase III transcription initiation."    Molecular Cell    DOI: 10.1016/j.molcel.2023.06.015 
      22. "TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease."    Nature Communications    DOI: 10.1038/s41467-023-39345-0 
      23. "Structure of human TRPV4 in complex with GTPase RhoA."    Nature Communications    DOI: 10.1038/s41467-023-39346-z 
      24. "Virion glycosylation influences mycobacteriophage immune recognition."    Cell Host & Microbe    DOI: 10.1016/j.chom.2023.05.028 
      25. "30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2304128120 
      26. "Structural interplay of anesthetics and paralytics on muscle nicotinic receptors."    Nature Communications    DOI: 10.1038/s41467-023-38827-5 
      27. "Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ."    Science Advances    DOI: 10.1126/sciadv.adg2838 
      28. "Cryo-EM structure of the Saccharomyces cerevisiae Rpd3L histone deacetylase complex."    Nature Communications    DOI: 10.1038/s41467-023-38687-z 
      29. "Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain"    eLife    DOI: 10.7554/eLife.88058 
      30. "Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor."    Blood Journal    DOI: 10.1182/blood.2023020181 
      31. "Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein."    Nature Communications    DOI: 10.1038/s41467-023-38352-5 
      32. "Structural mechanisms of TRPM7 activation and inhibition."    Nature Communications    DOI: 10.1038/s41467-023-38362-3 
      33. "Human TRPV1 structure and inhibition by the analgesic SB-366791."    Nature Communications    DOI: 10.1038/s41467-023-38162-9 
      34. "Cryo-EM structure of the human Sirtuin 6–nucleosome complex"    Science Advances    DOI: 10.1126/sciadv.adf7586 
      35. "Sensory specializations drive octopus and squid behaviour."    Nature    DOI: 10.1038/s41586-023-05808-z 
      36. "Structural basis of sensory receptor evolution in octopus."    Nature    DOI: 10.1038/s41586-023-05822-1 
      37. "Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions."    Molecular Cell    DOI: 10.1016/j.molcel.2023.03.006 
      38. "Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase."    ACS Nano    DOI: 10.1021/acsnano.3c00463 
      39. "Cryo-EM structure of amyloid fibril formed by α-synuclein hereditary A53E mutation reveals a distinct protofilament interface"    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2023.104566 
      40. "rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly."    Nature Communications    DOI: 10.1038/s41467-023-36867-5 
      41. "Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel."    Cell Reports    DOI: 10.1016/j.celrep.2023.112124 
      42. "Cross-protective antibodies against common endemic respiratory viruses."    Nature Communications    DOI: 10.1038/s41467-023-36459-3 
      43. "Nodavirus RNA replication crown architecture reveals proto-crown precursor and viral protein A conformational switching."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2217412120 
      44. "Cryo-EM structure of adeno-associated virus 4 at 2.2 Å resolution"    Acta Crystallographica Section D Structural Biology    DOI: 10.1107/S2059798322012190 
      45. "The molecular mechanism of sialic acid transport mediated by Sialin."    Science Advances    DOI: 10.1126/sciadv.ade8346 
      46. "Cryo-EM reveals the molecular basis of laminin polymerization and LN-lamininopathies."    Nature Communications    DOI: 10.1038/s41467-023-36077-z 
      47. "Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1."    Structure    DOI: 10.1016/j.str.2022.12.014 
      48. "Structural basis of ferroportin inhibition by minihepcidin PR73."    PLOS Biology    DOI: 10.1371/journal.pbio.3001936 
      49. "Mechanism of Ca2+ transport by ferroportin."    eLife    DOI: 10.7554/eLife.82947 
      50. "A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability."    Structure    DOI: 10.1016/j.str.2022.12.012 
      51. "Inhibition of the proton-activated chloride channel PAC by PIP2."    eLife    DOI: 10.7554/eLife.83935 
      52. "Changes within the central stalk of E. coli F1Fo ATP synthase observed after addition of ATP."    Communications Biology    DOI: 10.1038/s42003-023-04414-z 
      53. "Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5"    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-022-00889-2 
      54. "Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus."    Nature    DOI: 10.1038/s41586-022-05583-3 
      2022
      1. "Sequence-specific remodeling of a topologically complex RNP substrate by Spb4."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-022-00874-9 
      2. "Mechanism of mixed-linkage glucan biosynthesis by barley cellulose synthase-like CslF6 (1,3;1,4)-β-glucan synthase."    Science Advances    DOI: 10.1126/sciadv.add1596 
      3. "A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases."    Communications Biology    DOI: 10.1038/s42003-022-04173-3 
      4. "Transient Prenyltransferase-Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase."    Biochemistry    DOI: 10.1021/acs.biochem.2c00509 
      5. "Structural principles of B cell antigen receptor assembly."    Nature    DOI: 10.1038/s41586-022-05412-7 
      6. "Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP"    Science    DOI: 10.1126/science.add1268 
      7. "Structures of the TMC-1 complex illuminate mechanosensory transduction."    Nature    DOI: 10.1038/s41586-022-05314-8 
      8. "Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria."    Nature Communications    DOI: 10.1038/s41467-022-33505-4 
      9. "Structural basis for APE1 processing DNA damage in the nucleosome."    Nature Communications    DOI: 10.1038/s41467-022-33057-7 
      10. "Methotrexate recognition by the human reduced folate carrier SLC19A1."    Nature    DOI: 10.1038/s41586-022-05168-0 
      11. "The promise of cryo-EM to explore RNA structural dynamics."    Journal of Molecular Biology    DOI: 10.1016/j.jmb.2022.167802 
      12. "Cryo-EM Structure and Functional Studies of EBNA1 Binding to the Family of Repeats and Dyad Symmetry Elements of Epstein-Barr Virus"    Journal of Virology    DOI: 10.1128/jvi.00949-22 
      13. "Cryo-EM reveals an entangled kinetic trap in the folding of a catalytic RNA."    Science Advances    DOI: 10.1126/sciadv.abq4144 
      14. "Visualization of conformational changes and membrane remodeling leading to genome delivery by viral class-II fusion machinery."    Nature Communications    DOI: 10.1038/s41467-022-32431-9 
      15. "Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities."    Nature Communications    DOI: 10.1038/s41467-022-32212-4 
      16. "Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition."    eLife    DOI: 10.7554/eLife.79736 
      17. "Conformational landscape of the yeast SAGA complex as revealed by cryo-EM."    Scientific Reports    DOI: 10.1038/s41598-022-16391-0 
      18. "Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-022-00798-4 
      19. "Structural basis for inhibition and regulation of a chitin synthase from Candida albicans."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-022-00791-x 
      20. "Structure of the human cation–chloride cotransport KCC1 in an outward-open state."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2109083119 
      21. "Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody."    Science Advances    DOI: 10.1126/sciadv.abp9151 
      22. "Architecture of the linker-scaffold in the nuclear pore."    Science    DOI: 10.1126/science.abm9798 
      23. "Superimmunity by pan-sarbecovirus nanobodies."    Cell Reports    DOI: 10.1016/j.celrep.2022.111004 
      24. "Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis."    Nature Communications    DOI: 10.1038/s41467-022-30602-2 
      25. "Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine."    Nature Communications    DOI: 10.1038/s41467-022-30537-8 
      26. "Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide."    Nature Communications    DOI: 10.1038/s41467-022-30407-3 
      27. "Ligand-Binding Sites in Vanilloid-Subtype TRP Channels."    Frontiers in Pharmacology    DOI: 10.3389/fphar.2022.900623 
      28. "Active conformation of the p97-p47 unfoldase complex."    Nature Communications    DOI: 10.1038/s41467-022-30318-3 
      29. "Computational design of mechanically coupled axle-rotor protein assemblies."    Science    DOI: 10.1126/science.abm1183 
      30. "Cryo-EM structure of the prothrombin-prothrombinase complex."    Blood    DOI: 10.1182/blood.2022015807 
      31. "Structural basis for inhibition of the drug efflux pump NorA from Staphylococcus aureus."    Nature Chemical Biology    DOI: 10.1038/s41589-022-00994-9 
      32. "Structural mechanism of muscle nicotinic receptor desensitization and block by curare."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-022-00737-3 
      33. "Recovery of particulate methane monooxygenase structure and activity in a lipid bilayer."    Science    DOI: 10.1126/science.abm3282 
      34. "The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation."    Nature Communications    DOI: 10.1038/s41467-022-28811-w 
      35. "Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids."    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2022.101793 
      36. "Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P"    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2120404119 
      37. "Gating choreography and mechanism of the human proton-activated chloride channel ASOR."    Science Advances    DOI: 10.1126/sciadv.abm3942 
      38. "An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii."    mBio    DOI: 10.1128/mbio.03732-21 
      39. "Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II."    Molecular Cell    DOI: 10.1016/j.molcel.2021.12.020 
      2021
      1. "Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography."    eLife    DOI: 10.7554/eLife.74512 
      2. "Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter."    Nature Chemical Biology    DOI: 10.1038/s41589-021-00936-x 
      3. "Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer."    Communications Biology    DOI: 10.1038/s42003-021-02916-2 
      4. "NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation."    Cell    DOI: 10.1016/j.cell.2021.11.011 
      5. "Illumination of serotonin transporter mechanism and role of the allosteric site."    Science Advances    DOI: 10.1126/sciadv.abl3857 
      6. "A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure."    Science    DOI: 10.1126/science.abe8526 
      7. "Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole."    Nature Communications    DOI: 10.1038/s41467-021-26608-x 
      8. "Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides"    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2109441118 
      9. "Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease."    Nature Communications    DOI: 10.1038/s41467-021-26161-7 
      10. "Purification and cryo-EM structure determination of Arabidopsis thaliana GLR3.4."    STAR Protocols    DOI: 10.1016/j.xpro.2021.100855 
      11. "Architecture and assembly mechanism of native glycine receptors."    Nature    DOI: 10.1038/s41586-021-04022-z 
      12. "Structural basis of chromatin regulation by histone variant H2A.Z."    Nucleic Acids Research    DOI: 10.1093/nar/gkab907 
      13. "Tunable Heteroassembly of a Plant Pseudoenzyme-Enzyme Complex."    ACS Chemical Biology    DOI: 10.1021/acschembio.1c00475 
      14. "Micropatterning Transmission Electron Microscopy Grids to Direct Cell Positioning within Whole-Cell Cryo-Electron Tomography Workflows."    Journal of Visualized Experiments    DOI: 10.3791/62992 
      15. "AAA+ ATPase p97/VCP mutants and inhibitor binding disrupt inter-domain coupling and subsequent allosteric activation."    Journal of Biological Chemistry    DOI: 10.1016/j.jbc.2021.101187 
      16. "Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole."    EMBO reports    DOI: 10.15252/embr.202153233 
      17. "Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation."    Science Advances    DOI: 10.1126/sciadv.abj4282 
      18. "The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter."    Nature Communications    DOI: 10.1038/s41467-021-25363-3 
      19. "Structural and mechanistic basis for protein glutamylation by the kinase fold."    Molecular Cell    DOI: 10.1016/j.molcel.2021.08.007 
      20. "Molecular mechanism of prestin electromotive signal amplification."    Cell    DOI: 10.1016/j.cell.2021.07.034 
      21. "Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport."    PLOS Biology    DOI: 10.1371/journal.pbio.3001370 
      22. "HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases."    Structure    DOI: 10.1016/j.str.2021.07.002 
      23. "Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation"    Nature    DOI: 10.1038/s41586-021-03716-8 
      24. "Structural basis for potassium transport in prokaryotes by KdpFABC."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2105195118 
      25. "Accurate prediction of protein structures and interactions using a three-track neural network."    Science    DOI: 10.1126/science.abj8754 
      26. "Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP."    Journal of General Physiology    DOI: 10.1085/jgp.202112873 
      27. "Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-021-00615-4 
      28. "Heat-dependent opening of TRPV1 in the presence of capsaicin."    Nature Structural & Molecular Biology    DOI: 10.1038/s41594-021-00616-3 
      29. "Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4."    Molecular Cell    DOI: 10.1016/j.molcel.2021.05.025 
      30. "Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection."    Nature Communications    DOI: 10.1038/s41467-021-23878-3 
      31. "Structural insight on assembly-line catalysis in terpene biosynthesis."    Nature Communications    DOI: 10.1038/s41467-021-23589-9 
      32. "Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment."    Immunity    DOI: 10.1016/j.immuni.2021.04.024 
      33. "Mechanosensitive channel YnaI has lipid-bound extended sensor paddles."    Communications Biology    DOI: 10.1038/s42003-021-02122-0 
      34. "Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition."    Nature    DOI: 10.1038/s41586-021-03540-0 
      35. "Structural basis of long-range to short-range synaptic transition in NHEJ."    Nature    DOI: 10.1038/s41586-021-03458-7 
      36. "Extracellular cap domain is an essential component of the TRPV1 gating mechanism."    Nature Communications    DOI: 10.1038/s41467-021-22507-3 
      37. "Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM."    Structure    DOI: 10.1016/j.str.2021.03.012 
      38. "Cryo-EM structure of a thermostable bacterial nanocompartment."    IUCrJ    DOI: 10.1107/S2052252521001949 
      39. "Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation."    Nature Communications    DOI: 10.1038/s41467-021-21816-x 
      40. "Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy."    Methods in Enzymology Ion Channels: Channel Production and Optical Methods    DOI: 10.1016/bs.mie.2021.02.008 
      41. "Structure and gating mechanism of the α7 nicotinic acetylcholine receptor"    Cell    DOI: 10.1016/j.cell.2021.02.049 
      42. "DPP9 sequesters the CÂ terminus of NLRP1 to repress inflammasome activation."    Nature    DOI: 10.1038/s41586-021-03350-4 
      43. "TRPV3 expression and purification for structure determination by Cryo-EM."    Methods in Enzymology Ion Channels: Channel Biochemistry, Reconstitution, and Function    DOI: 10.1016/bs.mie.2021.02.006 
      44. "Structure of the human Mediator-bound transcription preinitiation complex."    Science    DOI: 10.1126/science.abg3074 
      45. "CorRelator: Interactive software for real-time high precision cryo-correlative light and electron microscopy."    Journal of Structural Biology    DOI: 10.1016/j.jsb.2021.107709 
      46. "Structure and inhibition mechanism of the human citrate transporter NaCT."    Nature    DOI: 10.1038/s41586-021-03230-x 
      47. "Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery."    Biomaterials Science    DOI: 10.1039/D0BM01947J 
      48. "Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction."    Nature Communications    DOI: 10.1038/s41467-020-20775-z 
      49. "Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes."    Nature Communications    DOI: 10.1038/s41467-020-20320-y 
      2020
      1. "Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases."    Molecular Cell    DOI: 10.1016/j.molcel.2020.11.047 
      2. "Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease."    Nature Communications    DOI: 10.1038/s41467-020-19887-3 
      3. "The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states."    Nucleic Acids Research    DOI: 10.1093/nar/gkaa1133 
      4. "Structure of bacterial phospholipid transporter MlaFEDB with substrate bound."    eLife    DOI: 10.7554/eLife.62518 
      5. "Structural Basis for Virulence Activation of Francisella tularensis."    Molecular Cell    DOI: 10.1016/j.molcel.2020.10.035 
      6. "The Structure of an AAV5-AAVR Complex at 2.5 Å Resolution: Implications for Cellular Entry and Immune Neutralization of AAV Gene Therapy Vectors"    Viruses    DOI: 10.3390/v12111326 
      7. "A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel."    Neuron    DOI: 10.1016/j.neuron.2020.10.014 
      8. "Light-coupled cryo-plunger for time-resolved cryo-EM."    Journal of Structural Biology    DOI: 10.1016/j.jsb.2020.107624 
      9. "Shared structural mechanisms of general anaesthetics and benzodiazepines."    Nature    DOI: 10.1038/s41586-020-2654-5 
      10. "Structural basis for the reaction cycle of DASS dicarboxylate transporters."    eLife    DOI: 10.7554/eLife.61350 
      11. "Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å."    Nature Communications    DOI: 10.1038/s41467-020-18120-5 
      12. "Structural basis of transcription-translation coupling."    Science    DOI: 10.1126/science.abb5317 
      13. "Molecular principles of assembly, activation, and inhibition in epithelial sodium channel."    eLife    DOI: 10.7554/eLife.59038 
      14. "Subdomain cryo-EM structure of nodaviral replication protein A crown complex provides mechanistic insights into RNA genome replication."    Proceedings of the National Academy of Sciences    DOI: 10.1073/pnas.2006165117 
      15. "Chemical and structural investigation of the paroxetine-human serotonin transporter complex."    eLife    DOI: 10.7554/eLife.56427 
      16. "The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity"    eLife    DOI: 10.7554/eLife.56527 
      17. "Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch."    Nature Communications    DOI: 10.1038/s41467-020-16387-2 
      18. "Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery."    Nano Letters    DOI: 10.1021/acs.nanolett.0c01386 
      19. "Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins."    Neuron    DOI: 10.1016/j.neuron.2020.03.012 
      20. "Structures of Three Actinobacteriophage Capsids: Roles of Symmetry and Accessory Proteins."    Viruses    DOI: 10.3390/v12030294 
      21. "Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy."    Nature Communications    DOI: 10.1038/s41467-020-14790-3 
      2019
      1. "Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement"    eLife    DOI: 10.7554/eLife.54449