Cells identify possible threats and create danger signals through the use of canonical inflammasomes, which are formed via the C-Terminal (CT) of sensor proteins NLRP1 and CARD8. By using cryo-EM to resolve the structures of NLRP1-CT and CARD8-CT complexes, the architecture and mechanisms of these complexes can be better understood. Citation: “Novel mode of filament formation in UPA-promoted CARD8 and NCRP1 inflammasomes” L. Robert Hollingsworth, Liron David, Yang Li, Andrew R. Griswald, Humayun Sharif, Pietro Fontana, Tian-Min Fu, Jianbin Ruan, Danial A. Bachovchin, Hao Wu. (2020)