The presence of lipids changes the way that cells and tissues transfer metabolic and electrical messages through gap junctions. Embedding connexin-46/50 intercellular channels into a dual lipid membrane system and resolving the structure at high resolution using Cryo-EM provides new insights into how lipids stabilize intercellular channels and vice versa.

Citation: "Connexin-46/50 in a dynamic lipid environment resolved by CryoEM at 1.9 Å" Jonathan A. Flores, Bassam G. Haddad, Kimberly A. Dolan, Janette B. Myers, Craig C. Yoshioka, Jeremy Copperman, Daniel M. Zuckerman, and Steve L. Reichow (2020)