Major instrumentation available at PNCC include 1 FEI Talos Arctica and 4 FEI Titan Krios instruments for training, sample screening and high-resolution data acquisition. Gatan K2 Direct Electron Detectors and sample autoloaders are installed on all microscopes for optimal resolution and throughput. One Titan Krios incorporates a FEI phase plate for high-contrast applications in both cryo-electron tomography and single particle imaging. In addition, PNCC maintains a wide array of equipment sample characterization and preparation using single particle and tomography methods.